Molecular Biology of the Skin: The Keratinocyte

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Michael Darmon, Miroslav Blumenberg
Academic Press, Dec 2, 2012 - Science - 291 pages
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Molecular Biology of the Skin: The Keratinocyte comprehensively reviews the major aspects of keratinocyte and epidermal differentiation, physiology, and pathology, primarily focusing on the molecular aspects. This exciting new resource discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatological pathology. The volume also highlights areas of genetic disease, new animal models to help in understanding dermatological disorders, and gene therapy using skin as a target. W.W. Franke, a pioneer in the study of the molecular biology of keratins, has written the foreword for the book.
Molecular Biology of the Skin: The Keratinocyte is intended for use by dermatologists and basic researchers in cell and developmental biology. It will also be valuable for surgeons and other clinicians as well as researchers in gene therapy, virology, and pharmacology.

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* Reviews keratinocyte (and epidermal) differentiation. physiology, and pathology, focusing on the molecular aspects
* -Discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatalogical pathology
* -Highlights genetic disease, new animal models, and gene therapy
 

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Contents

Chapter 1 Molecular Biology of Human Keratin Genes
1
Chapter 2 Murine Epidermal Keratins
33
Chapter 3 Phenotypic Expression and Processing of Filaggrin in Epidermal Differentiation
79
A Key Structure of Terminally Differentiating Keratinocytes
107
Chapte 5 Loricrin
151
Chapter 6 Retinoic Acid in Epithelial and Epidermal Differentiation
181
Chapter 7 Human Papillomavirus and Malignant Transformation
207
Chapter 8 Transgenic Mouse Models for the Study of the Skin
245
Chapter 9 Keratinocytes as a Target for Gene Therapy
269
Index
285
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