Molecular Cardiology in Clinical Practice

Front Cover
Michael R. Sanders, John B. Kostis
Springer Science & Business Media, Sep 30, 1999 - Medical - 226 pages
Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists.
With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems.
Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.
 

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Contents

INTRODUCTION TO MOLECULAR MEDICINE A CONTEMPORARY VIEW OF HEART FAILURE
1
MOLECULAR MECHANISMS OF MYOCARDIAL REMODELING
29
PATHOPHYSIOLOGY OF HEART FAILURE IN REGURGITANT VALVULAR DISEASES RELATION TO VENTRICULAR DYSFUNCTION AN...
43
CORONARY ATHEROTHROMBOSIS PATHOPHYSIOLOGY AND CLINICAL IMPLICATIONS
57
PREVENTION OF ATHEROSCLEROSIS ENDOTHELIAL FUNCTION CHOLESTEROL AND ANTIOXIDANTS
76
Physiologic and Pathophysiologic Effects of Angiotensin in the Heart and Vessel Wall
107
REGULATION OF INFLAMMATION BY FAS LIGAND EXPRESSION ON THE VASCULAR ENDOTHELIUM
125
MOLECULAR MECHANISMS OF PLATELET ACTIVATION AND INHIBITION
143
MOLECULAR DETERMINANTS OF THE T WAVE
168
SEXUAL DIMORPHISM IN CARDIOVASCULAR DISEASE
187
INDEX
219
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