Molecular Chaperones and Cell SignallingThis book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones? |
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Índice
Changing Paradigms of Protein Trafficking and Protein Function | 43 |
Extracellular Biology of Molecular Chaperones Molecular Chaperones as Cell Regulators | 97 |
Extracellular Biology of Molecular Chaperones Physiological and Pathophysiological Signals | 193 |
Extracellular Biology of Molecular Chaperones Molecular Chaperones as Therapeutics | 249 |
Extracellular Biology of Molecular Chaperones What Does the Future Hold? | 319 |
| 327 | |
Otras ediciones - Ver todo
Molecular Chaperones and Cell Signalling Brian Henderson,A. Graham Pockley Vista previa restringida - 2005 |
Molecular Chaperones and Cell Signalling Brian Henderson,A. Graham Pockley No hay ninguna vista previa disponible - 2011 |
Molecular Chaperones and Cell Signalling Brian Henderson,A. Graham Pockley No hay ninguna vista previa disponible - 2005 |
Términos y frases comunes
Acad Sci USA activity adaptive immune adjuvant anti-inflammatory antibodies antigen apoptosis arthritis autoimmune bacterial binding Biochem Biol Chem Brenneman cancer CD4+ T cells CD8+ Cell Biol cell responses cell surface cellular chaperonin Chapter clones complex cytokine cytosol dendritic cells diabetes disease early pregnancy factor enzyme exogenous expression extracellular findings first function gene Gozes GroEL heat shock factor heat shock protein human identified immune responses immune system immunisation Immunol induce inflammation inflammatory inhibit inhibitor innate immune interactions involved kinase leaderless levels ligand lymphocytes macrophages maturation mechanism mediated membrane mice mitochondria molecular chaperones molecules monocytes moonlighting proteins mycobacterial Natl Acad Sci neuroprotective peptide pro-inflammatory Proc Natl Acad protein 70 protein folding regulation regulatory release role secretion secretory shock protein 60 shock protein gp96 significant specific Srivastava stimulation stress proteins studies tein tion tissue TLR2 TLR4 TLRs Toll-like receptor transcription factor vitro
Información bibliográfica
| Título | Molecular Chaperones and Cell Signalling |
| Editores | Brian Henderson, A. Graham Pockley |
| Editor | Cambridge University Press, 2005 |
| ISBN | 1139444018, 9781139444019 |
| Exportar cita | BiBTeX EndNote RefMan |