Molecular Epidemiology: Principles and Practices

Front Cover
Paul A. Schulte, Frederica P. Perera
Academic Press, Feb 20, 1998 - Science - 588 pages
This book serves as a primer for laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology builds on the developments and techniques of molecular biology, providing powerful tools to supplement or improve epidemiological research to identify exposure, disease, or susceptibility in human populations. It assists traditional epidemiologists in reducing misclassification, understanding mechanisms, and identifying risks to individuals and groups.
Molecular Epidemiology is a compendium of the principles for and practice of Molecular epidemiology. Focusing on methods for using biological markers in epidemiological research, this book explores markers relevant to a broad range of organ and disease systems research. It enumerates the considerations necessary for valid field research and provides a resource on the salient and subtle features of biomarkers. The book also includes discussions of statistics and validation, a review of issues pertaining to specimen collection, and a look at the sociological implications of using biological markers in epidemiological research.
 

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Contents

Chapter 2 Molecular Biology in Epidemiology
45
Chapter 3 Validation
79
Chapter 4 Technical Variability in Laboratory Data
109
Chapter 5 Biologic Monitoring and Pharrnacokinetic Modeling for the Assessment of Exposure
137
Chapter 6 Design Considerations in Molecular Epidemiology
159
Chapter 7 Statistical Methods in Molecular Epidemiology
199
A Resource for Molecular Epidemiologic Studies
217
Chapter 9 Interpretation and Communication of Molecular Epidemiological Data
235
Chapter 13 Cardiovascular Disease
341
Chapter 14 Genetic Disease
365
Chapter 15 Biologic Markers in the Epidemiology of Reproduction
385
Chapter 16 Immune Markers in Epidemiologic Field Studies
407
Chapter 17 Biomarkers of Pulmonary Disease
443
Chapter 18 Biologic Markers in the Genitourinary System
469
Chapter 19 Neurologic Disease
497
Chapter 20 Practical Applications of Biomarkers in the Study of Environmental Liver Disease
517

Chapter 10 Use of Biomarkers in Risk Assessment
251
PRACTICAL APPLICATIONS
275
Chapter 11 Carcinogenesis
277
Chapter 12 Infectious Disease
301
Chapter 21 Biomarkers of Musculoskeletal Disorders
547
Chapter 22 Epilogue
565
Index
571
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About the author (1998)

Dr. Schulte is an epidemiologist with interests in education, quantitative risk assessment, health communication, use of biological markers in epidemiologic research, intervention research, and genetics. In recent years, he has conducted extensive research on occupational cancer. He has focused on issues of dissemination of occupational safety and health information. Dr. Schulte is the editor of the textbook entitled, "Molecular Epidemiology: Principles and Practices." He has served as guest editor of the Journal of Occupational Medicine and the American Journal of Industrial Medicine and was on the initial editorial board of Cancer Epidemiology, Biomarkers and Prevention. He also has served as a consultant to various organizations such as the International Agency for Research on Cancer, the National Academy of Sciences, the Medical Research Council of the United Kingdom, WHO, the Pennsylvania Department of Health, the Agency for Toxic Substances and Disease Registry, and the Department of Energy.

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