Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins

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Rainer Fischer, Stefan Schillberg
John Wiley & Sons, Mar 6, 2006 - Science - 338 pages
Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels.
Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

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1 Efficient and Reliable Production of Pharmaceuticals in Alfalfa
2 Foreign Protein Expression Using Plant Cell Suspension and Hairy Root Cultures
3 Novel Sprouting Technology for Recombinant Protein Production
4 Monocot Expression Systems for Molecular Farming
5 The Field Evaluation of Transgenic Crops Engineered to Produce Recombinant Proteins
6 Plant Viral Expression Vectors History and New Developments
7 Production of Pharmaceutical Proteins in Plants and Plant Cell Suspension Cultures
8 Chloroplast Derived Antibodies Biopharmaceuticals and Edible Vaccines
11 Production of Spider Silk Proteins in Transgenic Tobacco and Potato
12 Gene Farming in Pea Under Field Conditions
13 Host Plants Systems and Expression Strategies for Molecular Farming
14 Downstream Processing of Plantderived Recombinant Therapeutic Proteins
15 Glycosylation of Plantmade Pharmaceuticals
16 Biosafety Aspects of Molecular Farming in Plants
17 A Topdown View of Molecular Farming from the Pharmaceutical Industry Requirements and Expectations
18 The Role of Science and Discourse in the Application of the Precautionary Approach

9 Plantderived vaccines progress and constraints
10 Production of Secretory IgA in Transgenic Plants

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About the author (2006)

Prof. Dr. Rainer Fischer, 45, currently Department Head of the Institute for Molecular Biotechnology (RWTH Aachen, Germany, 80 employees) and Senior Executive Director of the Fraunhofer Institute for Molecular Biology and Applied Ecology (170 employees). His research covers many areas of Molecular Biotechnology including Genomics, Proteomics, Cellomics, Protein Engineering, Molecular Medicine, Immunology, Virology, Plant Biotechnology, as well as the Production and Purification of Recombinant Proteins.
Within the last 15 years Prof. Dr. Rainer Fischer published over 90 research articles in leading international journals, 35 book chapters and established a strong global academic and industrial network. He is also well known within the scientific arenas for his international scientific talks, is on the editorial board of two highly ranked scientific journals and is reviewer for more than 20 journals. He has filed over 25 different patent applications and successfully secured more than 100 million Euros in financial support. Prof. Fischer serves as reviewer for multiple national and international grant agencies (EC, NATO and NSF), he is an adviser for four international Biotech companies and an active board member for two start-up companies.

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