Molecular Genetics & Gene Therapy of Cardiovascular Diseases

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CRC Press, Jan 2, 1996 - Science - 616 pages
Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases--including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nearly 50 investigators on the cutting-edge of pioneering research in the field.
 

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Contents

Molecular Genetics and Its Application to Understanding Cardiovascular Disease
1
A Nonmathematical Overview of Modern Gene Mapping Techniques Applied to Human Diseases
79
Moleeular Geneties of Human Hypertension
111
Arrhythmias and Vascular Disease
135
Molecular Genetic Studies of Inherited Cardiomyopathies
153
154 Seidman and Seidman
154
Hyperlipidemia Molecular Defects of Apolipoproteins B and E Responsible for Elevated Blood Lipids
173
Genetic Causes of Aortic Aneurysms
209
Hypertension Research with Genetically Altered Animals
321
Genetieally Altered Mouse Models of Lipoprotein Disorders and Atheroselerosis
345
Homologous Reeombination and Growth Factors
371
Gene Targeting of Adhesion Molecules in the Vasculature
403
Cardiogenesis and Moleeular Physiology
427
Gene Therapy for Cardiovascular Disease
467
GeneTransfer Approaches to Vascular Disease
487
GeneTransfer Approaches to Myocardial Diseases
513

Marfan Syndrome
219
Genetie Risk Factors for Myocardial Infarction
239
Using Animal Models to Dissect the Genetics of Complex Traits
271
Genetie Disseetion of Hypertension in Experimental Animal Models
293
Gene Therapy Approaches to Metabolie and Cardiovascular Disorders
529
Vascular SmoothMuscleCell Proliferation
547
Index
581
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