Molecular Genetics and Colorectal Neoplasia: A Primer for the Clinician
Understanding the genetic background of colorectal cancer iskey to optimal patient management. Genetics plays a role in diagnosis, screening, therapy, prognosis and surveillance of this disease as ithelps define the behaviour and natural history of particular types oftumors. Much of the molecular genetics behind colorectal cancer iscomplex and confusing, especially to busy practitioners who do nothave the time or opportunity to keep abreast of developments."Molecular Genetics of Colorectal Neoplasia A Primer for theClinician" provides the latest information on the genetics ofcolorectal cancer within a context of basic genetics, describing thesubject in understandable language and making it clinically relevant.In this way, clinicians can become familiar with genetic terms andtechniques related to colorectal neoplasia, providing a backgroundupon which to build an appreciation of future advances and an abilityto include them in the practicalities of patient care.This edition is intended for the healthcare provider or industryconcerned with colorectal neoplasia: including general and colorectalsurgeons, pathologists, oncologists, gastroenterologists, internalmedicine and family practice physicians, nurses, geneticists, counsellors, registry co-ordinators, epidemiologists, andstatisticians.
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abnormalities adenomas affected allele amino acids APC gene associated blood testing bowel cancer cells carcinoma cell cycle cell growth chromosome clinical clone codon colon cancer colonoscopy colorectal neoplasia cyclins desmoid tumors develop diagnosis DNA mismatch repair DNA repair DNA sequence dominant inheritance dominantly inherited duodenal dysplasia endoscopic enzyme epithelium exons familial adenomatous polyposis family history family tree FAP patients FIGURE function gene mutations genetic code genetic testing genome germ-cell mutations germline growth factors hereditary nonpolyposis colorectal history of colorectal hMLH1 hMSH2 HNPCC human inactivation inherited colorectal cancer inherited disease inherited syndrome IPAA linkage analysis malignant marker microsatellite molecular genetics molecule mRNA mucosa neoplasia neoplasm nonpolyposis colorectal cancer normal cells nucleotide occur oncogenes phenotype polymerase polymorphic polyps produce prophylactic surgery protein RAS gene recombinant rectal cancer relatives repair genes risk screening sequence of DNA strands surveillance transcription triplet tumor suppressor genes