Molecular Imaging I

Front Cover
Wolfhard Semmler, Markus Schwaiger
Springer Science & Business Media, Jul 15, 2008 - Medical - 280 pages

With the increasing interest in the experimental and clinical application of molecular imaging many institutions create research groups or interdisciplinary centers focussing on the complex development process of this new methodology. The aim for this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

 

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Contents

Fundamentals of Optical Imaging
3
MicroCT
23
PET SPECT Instrumentation
53
Magnetic Resonance Imaging and Spectroscopy
75
Ultrasound Basics
91
PETCT and PETMRI
108
Imaging Probes
133
Magnetic Resonance
135
Xray Contrast Agents and Molecular Imaging A Contradiction?
166
Molecular Imaging using Positron Emission Tomography
177
Optical Agents
202
Ultrasound Contrast Agents for Molecular Imaging
223
Agents for Polarization Enhancement in MRI
247
Index
273
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Page xxii - Gene mapping Determination of the relative positions of genes on a DNA molecule (chromosome or plasmid) and of the distance, in linkage units or physical units, between them. Gene...
Page xxvi - A chemical found in the nucleus and cytoplasm of cells; it plays an important role in protein synthesis and other chemical activities of the cell. The structure of RNA is similar to that of DNA. There are several classes of RNA molecules, including messenger RNA, transfer RNA, ribosomal RNA, and other small RNAs, each serving a different purpose.
Page xxii - Gene: The fundamental physical and functional unit of heredity. A gene is an ordered sequence of nucleotides located in a particular position on a particular chromosome that encodes a specific functional product (ie, a protein or RNA molecule).
Page xxii - Genetic code: The sequence of nucleotides, coded in triplets (codons) along the mRNA. that determines the sequence of amino acids in protein synthesis. The DNA sequence of a gene can be used to predict the mRNA sequence, and the genetic code can in turn be used to predict the amino acid sequence. Genetic engineering technology: See recombinant DNA technology.
Page xxv - ... for the protein. Proteins are required for the structure, function, and regulation of the body's cells, tissues, and organs; and each protein has unique functions. Examples are hormones, enzymes, and antibodies.
Page xxii - Gene expression: The process by which a gene's coded information is converted into the structures present and operating in the cell. Expressed genes include those that are transcribed into mRNA and then translated into protein and those that are transcribed into RNA but not translated into protein (eg, transfer and ribosomal RNAs).
Page xxii - Genetics: The study of the patterns of inheritance of specific traits. Genome: All the genetic material in the chromosomes of a particular organism; its size is generally given as its total number of base pairs. Genome...
Page xxiii - Molecular biology The study of the structure, function, and makeup of biologically important molecules. Molecular farming The development of transgenic animals to produce human proteins for medical use. Molecular genetics The study of macromolecules important in biological inheritance. Molecular medicine The treatment of injury or disease at the molecular level. Examples include the use of DNA-based diagnostic...