Molecular Insight of Drug DesignArli Aditya Parikesit The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution. |
Contents
Integrated Approach to Nature as Source of | 29 |
Molecular Classification of Antitubulin Agents with Indole Ring | 47 |
Targeting | 69 |
Multifunctional Nanoparticles for Successful Targeted Drug | 91 |
Common terms and phrases
Accessed October 26 acid activity ADRs adverse drug reactions adverse events agents Alzheimer’s disease antibodies anticancer antitubulin approach assessment Available benefit-risk Bioinformatics biological blood-brain barrier brain cancer carbon dots cellular Chemical clinical trials combinatorial cross the BBB database delivery of drug dendrimers dendrograms drug delivery drug design drug development drug discovery drug leads effective efficacy endocytosis endothelial cells entropy of information equipartition European Medicines Agency evaluation factor fluorescent function gene genomics H–OMe ICSRs imaging inhibitors International intracellular ischemic stroke Journal lead compound ligands liposomes Marine drugs matrix Medicinal Chemistry membrane models molecular molecules nanocarriers Nanomedicine nanoparticles Nanotechnology natural products neurons neuroprotective OMe H Parkinson’s disease patients peptide Pharmaceutical pharmacology pharmacovigilance phase polymeric post-marketing potential properties protein Qdots quantum dots receptor reported Research Reviews risk safety Sciences similarity matrix siRNA splits graph structure studies surface synthesis therapeutic therapy TMPs transport tubulin tumor uptake vector vitro vivo