Molecular Mechanisms In Cellular Growth and DifferentiationA.R. Bellve Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the roles of growth factors and receptors in cell differentiation and development, particularly, in pattern formation. The homeotic systems regulated intracellularly and the two differentiation systems thought to involve sequence-specific DNA-binding proteins in conjunction with small molecules are also explored. |
Contents
| 1 | |
POLYPEPTIDE GROWTH FACTORS AND THEIR CELL MEMBRANE RECEPTORSRELATION TO ONCOGENES | 129 |
POLYPEPTIDE GROWTH FACTORS AND THEIR CELL MEMBRANE RECEPTORS ROLE IN DIFFERENTIATION AND DEVELOPMENT | 185 |
SEQUENCESPECIFIC DNABINDING PROTEINS ROLE IN DIFFERENTIATION AND DEVELOPMENT | 259 |
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3T3 cells A—Au complexes Acad actin affinity aFGF albumin amino acid antibody assays bFGF binding sites Biochem capillary cDNA Cell Biol Cell Cambridge cell culture cell lines cell surface cell types cellular Chem cloned collagen contains cytoplasmic defined detected differentiation digit domain Drosophila EGF receptor embryo En-l encoded endothelial cells endothelium engrailed enzyme eve protein extracellular extract fibroblast findings first fragment function G proteins gene expression growth factor heparan sulfate heparin hepatocytes hepatoma homology hormones identified IGF-II induced insulin interactions laminin laminin receptor liver matrix medium mitogenic molecules mouse mRNA murine mutant Natl Nature London NIH 3T3 cells normal oncogene pattern peptide phosphorylation plasmalemma plasmalemmal vesicles probe Proc proliferation protein kinase activity proteoglycans purified region regulation residues retinoic acid sequence Sertoli cells specific structure studies synthesis TGFB tion tissue tissue-specific transcription transformed tumor cell tyrosine v-erbA vascular villin vitro vivo