Molecular Mechanisms of Werner’s Syndrome
During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
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Acad Sci USA amino acids apoptosis binding biochemical Biol Chem 2001 Bloom's syndrome Brosh camptothecin cancer cell cycle cell lines cellular checkpoint chromosome complex defects deletion DNA damaging agents DNA helicase DNA polymerase DNA repair DNA replication DNA structures DNA substrate DNA-PK double-strand duplex DNA eukaryotic exonuclease exonuclease activity exonuclease domain fibroblasts foci functional interaction Genes Dev genomic instability helicase activity helicase and exonuclease helicase domain Holliday junctions human cells human WRN inhibitors kinase Lebel molecular mouse Wrn mutations Natl Acad Sci normal nuclear pathway PCNA phase phenotype phosphorylation premature aging Proc Natl Acad RecQ helicases replication forks replicative senescence Saccharomyces cerevisiae senescence senescent cells sequence SGS1 Sgsl single-stranded srs2 stalled replication forks suggest that WRN syndrome helicase telomerase telomere tissue Top3 topoisomerase transcription unwinding vitro vivo Werner syndrome Werner syndrome gene Werner syndrome protein WRN exonuclease WRN gene WRN helicase WRN protein WS cells yeast