Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.
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accession number acid activation addition adducts alleles alter analysis apoptosis binding biological body cancer caspases catalysed catalytic cycle cause cell cellular Chapter chemically reactive chromatin chromosomes coding region complex compounds conjugate CYPs Cytochrome P450 damage database detoxification drug efavirenz enzymes etal examine excretion Exon exposure Figure Firstly function gene expression genetic genome glucuronidation glutathione hence human identified important increased individual induced interactions kidney large number levels ligand liver major MAPK metabolite mice microarray mixture molecular mechanisms molecules MPTP mRNA mutation occur organophosphates overall oxidative stress paracetamol pathways peroxisome peroxisome proliferators Phase II metabolism polymorphisms potential pregnane X receptor produce promoter protein proteomics reactions receptor RefSeq regulation reporter gene response elements response to toxic result risk assessment role seen sequence signalling species structure substrate SUl.Ts sulphotransferase Table target thalidomide toxic insult toxicity Toxicol toxicology toxins transcription factors transgenic xenobiotics