Molecular Toxicology

Front Cover
Garland Science, 2003 - Science - 150 pages
Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.
 

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Contents

Role of Phase I metabolism in toxicity
7
Role of Phase II metabolism in toxicity
25
Coordinated responses to toxicity
45
Toxicity case studies
63
The real world complex mixtures
87
Role of genetics in toxic response
99
Technologies for toxicity assessment
119
Index
145
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Tópicos de genética

No preview available - 2006

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