Molecular Toxicology

Front Cover
Molecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science--including drug metabolism, carcinogenesis, programmed cell death, and DNA repair--has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science. Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth.
Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.

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About the author (1997)

Philip David Josephy received his B.Sc. in physics from the University of Toronto, and his Ph.D. in medical biophysics from the University of British Columbia. He conducted postdoctoral research in Molecular Biophysics at NIEHS, North Carolina, and has been a Professor of Chemistry andBiochemistry at the Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph, Canada, since 1983.

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