Molecular and Cell Biological Aspects of Gastroenteropancreatic Neuroendocrine Tumor Disease, Volume 733
New York Academy of Sciences, Jan 1, 1994 - Medical - 535 pages
New molecular and cell biological approaches in the fields of neurobiology and neuroendocrinology have identified a large number of molecules that can be assigned structurally and functionally to various subcellular structures, such as secretory vesicles, the Golgi complex, the trans-Golgi network, and endosomes. It has become evident that neurons and neuroendocrine cells share many properties, such as the expression of very similar secretory vesicles and molecules, including cell adhesion molecules, neurotransmitters, hormones, neurotransmitter-receptors and hormone-receptors. Various molecules discovered and characterised in basic research have been found to be increasingly applicable for improved diagnosis and therapy of neuroendocrine tumour disease. This volume reviews current research in both basic science and clinical research from the viewpoint of its direct applicability to clinical medicine.
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Classification of Normal and Neoplastic Neuroendocrine Cells By Gunter
Pathogenesis and Diagnosis of Enterochromaffinlike Cell Tumors
Transcriptional Basis of
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Acad activity adrenal amine amino acid antibodies binding Biochem brain Ca2+ channels calcium Cancer carcinoid heart disease carcinoid syndrome carcinoid tumors carcinoma Cell Biol cell line Chem chromaffin cells chromaffin granules chromogranin clinical cloned culture cytoplasmic demonstrated differentiation disease domain ECL cell effect endocrine cells exocytosis expression function fusion G proteins gastric gastrin gastrinoma gene glycine receptor growth factor H,K-ATPase histamine hormone human inhibition inhibitory interaction intestinal intracellular isoforms lamina propria liver loxtidine markers membrane proteins MEN1 metastases molecular molecules mucosa Natl neural neuroendocrine cells neuroendocrine tumors neurons neurotoxins neurotransmitter octreotide p-subunit pancreatic tumors pathway patients peptide pituitary plasma membrane Proc protein kinase regulated release role secretion secretory granules sequence signal somatostatin analogue somatostatin receptors specific SS receptors stimulation studies substrate subtypes subunit synaptic vesicles synaptobrevin synaptophysin synaptotagmin syntaxin tissue toxin transplantation transporter treatment tumor cells uptake vesicular vitro