Molecular and Functional Models in Neuropsychiatry

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Jim J. Hagan
Springer Science & Business Media, Apr 2, 2011 - Medical - 394 pages
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The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

 

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Contents

Drosophila as a Model Organism for the Study of Neuropsychiatric Disorders
37
Transgenic Animal Models of Huntingtons Disease
61
Heuristics and Challenges
87
Molecular Perspectives
121
Animal Models of ADHD
148
Testing Hypotheses About Molecular Mechanisms
187
Advances in Animal Models of Drug Addiction
213
The Contribution of Animal Models to Understanding Epigenetic Mechanisms in Affective Disorders and Resilience
251
Animal Models of Epigenetic Regulation in Neuropsychiatric Disorders
281
Functional and Pharmacological MRI in Understanding Brain Function at a Systems Level
323
The Pig as a Model Animal for Studying Cognition and Neurobehavioral Disorders
358
Index
385
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