Molecular and Cellular Mechanisms of Human Hypersensitivity and Autoimmunity: Proceedings of a Cetus-Upjohn-UCLA Symposium, Held at Keystone, Colorado, April 17-23, 1988
Edward J. Goetzl
Liss, 1989 - Allergy - 194 pages
A molecular and cellular biological approach to human immuno-deficiency and autoimmunity. Coverage includes descriptions of the cytokines and cellular mediators necessary for integrated and well-regulated immune responses. The antigenic stimuli, histocompatibility variants, lymphocytic defects and effector cell abnormalities central to selected human hypersensitivity and autoimmune diseases are also covered, as are molecular strategies to novel therapies for immune diseases using monoclonal antibodies or receptor-specific immunotoxins.
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Normal and Mutant Human Adenosine Deaminase Genes
Mechanisms of LymphocyteMediated Lysis
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Acad Sci USA ADA activity ADA mRNA alleles amino acid analysis anti-CD5 antibody response antigen arthritis beta cell binding CD4+ CD8+ T cells cDNA cell lines cellular class 1 MHC cloned T cells corneal CTLs cultured cytokines cytolytic cytotoxic Dinarello disease effect exon fibroblasts flare-up reactions function gene growth factor H1 receptors helper T cells hnRNP homology human Hypersensitivity and Autoimmunity IDDM IgE production IgE synthesis IgE-PF immune Immunol Immunology inflammatory inhibit injection intron islets joint inflammation leukocytes LTB4 lymphocytes lysis macrophages mBSA membrane mice molecular molecules monoclonal antibody monocytes mouse mRNA murine mutations Natl Acad Sci Nepom NK cells normal nucleic acids peptide perforin plasma PMN leukocytes present Proc Natl Acad protein purified rats recombinant reovirus role sequence sera SLE patients specific splicing stimulation supernatants T-cell T-cell clones target cells tissue TNF-a vitro vivo