Molecular and Cytogenetic Studies of Non-disjunction: Proceedings of the Fifth Annual National Down Syndrome Society Symposium Held in New York, N.Y., December 1-2, 1988
Trisomy 21 is the most common genetic disorder in humans. The present volume reviews the results of molecular and cytogenetic techniques performed on four organisms--humans, mice, "Drosophila," and yeast. Examined are the association between meiotic recombination and chromosome disjunction, increasing maternal age and non-disjunction in humans, and genetic factors that may contribute to a predisposition to non-disjunction. Molecular analyses involving different human chromosomes, the importance of tissue-specific trisonomy, and the significance of specific etiological agents to non-disjunction are also considered.
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Issues Pertaining to the Impact and Etiology of Trisomy 21 and Other
Stylianos E Antonarakis Andrew C Warren Mary Kay McCormick
NONDISJUNCTION IN HUMANS
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alleles analysis aneuploidy Antonarakis associated autosomal trisomies bivalents centromere Chakravarti chiasma chiasmata chorionic chromosome 21 chromosome abnormalities chromosome segregation conceptuses confined placental mosaicism crossover cytogenetic cytological detected diploid distributive disjunction distributive segregation DNA markers Drosophila melanogaster DS phenotype embryos errors evidence exchange factors females fertilization fetal fourth chromosomes frequency of trisomy gene gene-centromere Genomics genotype gestation Hassold heteromorphisms heterozygous homologous homozygous Hook EB hyperhaploidy hypothesis increasing maternal age Jacobs karyotype linkage loci locus males maternal age effect maternal meiosis mechanism meiosis meiotic meiotic division meiotic recombination meiotic stage mer1 metaphase mice microtubules mitotic mouse mutant nondis junction nondisjunction nonexchange normal chromosome observed occur offspring oocytes ovarian teratomas ovulation pairing parental origin patients polymorphisms pregnancies probes recombination RED1 relaxed selection sequences sex chromosome Slaugenhaupt sperm spindle spontaneous abortions spores strains syndrome Table teratomas tetrads translocation trisomy 13 trisomy 21 vitro X chromosome YACs