Molecular and Cytogenetic Studies of Non-disjunction: Proceedings of the Fifth Annual National Down Syndrome Society Symposium Held in New York, N.Y., December 1-2, 1988

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Trisomy 21 is the most common genetic disorder in humans. The present volume reviews the results of molecular and cytogenetic techniques performed on four organisms--humans, mice, "Drosophila," and yeast. Examined are the association between meiotic recombination and chromosome disjunction, increasing maternal age and non-disjunction in humans, and genetic factors that may contribute to a predisposition to non-disjunction. Molecular analyses involving different human chromosomes, the importance of tissue-specific trisonomy, and the significance of specific etiological agents to non-disjunction are also considered.

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Issues Pertaining to the Impact and Etiology of Trisomy 21 and Other
Stylianos E Antonarakis Andrew C Warren Mary Kay McCormick

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