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acid action potential activity adenylate cyclase adrenergic receptors agents alkylating amino azaheterocycles antigen antiviral Biochem Biol bleomycin blood Bordetella pertussis Bordetella pertussis adenylate Br-daunomycin Ca2+ calcium calmodulin Carafoli carcinogenic cardiolipin catecholamines cell lines cellular channels Chem chemical chronic clinical clones complex compounds concentration coronary covalent binding cystamine cytochrome cytosolic cytotoxic decrease DNA repair drug effects EGF-r enzyme function gene glutathione Gorrod hepatic hepatocytes hepatotoxicity human hypertensive increased incubated induced infection inhibition inhibitors interaction intracellular ischaemia isolated ketanserin lesions leukaemia levels lymphocytes mammalian mechanisms menadione metabolism metabolite Methisoprinol microsomes mitochondria molecular mutagenic myelinated nerve fibres N-oxidation normal oncogenes oxidation pathway patients pertussis adenylate cyclase Pharmacol Pharmacology phosphorylation plasma membrane platelets polypeptides protein purified rat liver reaction reactive intermediates reductase REF52 cells response role serotonin smooth muscle sodium specific studies synthesis thiol tissue toxicity treatment tumours vascular vasoconstrictor virus vitro vivo