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Recent developments in antiviral drug targeting
The molecular basis for ethanolinduced liver injury
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acid action potential adenylate cyclase adrenergic receptors adriamycin agents alkylating amino azaheterocycles antigens antiviral Biochem Biol bleomycin blood Bordetella pertussis Bordetella pertussis adenylate Br-daunomycin Ca2+ calcium calmodulin carcinogens cardiolipin catecholamines cell lines cellular channels Chem chemical chronic clinical clones complex compounds concentration covalent binding cystamine cytochrome cytosolic cytotoxic decrease DNA repair drug effects enzyme function gene glutathione Gorrod hepatic hepatocytes hepatotoxicity human hypertensive increased incubated induced infection inhibition inhibitors interaction intracellular isolated ketanserin lesions levels liver diseases lymphocytes mammalian mechanisms menadione metabolic activation metabolite Methisoprinol microsomes mitochondria molecular mutagenic myelinated nerve fibres N-oxidation normal Nueten oncogenes Orrenius oxidation pathway patients pertussis adenylate cyclase Pharmacol plasma membrane platelets polypeptides protein purified rat liver reaction reactive intermediates receptor reductase REF52 cells response role serotonin sodium specific studies synthesis thiol tissue toxicity treatment ttte Vanhoutte vascular vasoconstrictor virus vitro vivo