Molecular biology of aging: proceedings of a UCLA Colloquium held at Santa Fe, New Mexico, March 4-10, 1989, Volume 123
Wiley-Liss, 1990 - Medical - 430 pages
This broad ranging study explores the recent findings in the dynamic field of molecular biogerontology. It examines the numerous molecular changes which occur during senescence and pinpoints the basic biological pacemakers of aging. Investigators examine the importance of DNA damage and the extent of differential gene expression during aging. There are discussions of attempts to manipulate the lifespans of various model organisms through gene transfer and regulated gene expression. Throughout, the contributors stress that the genome holds the ultimate key to understanding the limits of lifespan and the determinants of senescence.
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Genetics of LongerLived DrosophUa
DNA Repair in Differentiating Cells in Relation to Aging
DNA Repair in the Nematode Caenorhabditis elegans
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17a-hydroxylase Acad Sci USA acid aging analysis antioxidant assay Biochem Biol Chem Biology bovine adrenocortical cells Caenorhabditis Caenorhabditis elegans catalase cell cycle cell death cell lines cellular chromosome clones cultures Davies KJA decrease degradation differentiated disease DNA damage DNA polymerase DNA repair donor Drosophila melanogaster effect eleaans endonuclease enzyme fibroblasts Figure fragments free radical function gene expression genetic genome glucocorticoids glycosylase glycosylation growth human fibroblasts hybridization hypoxia hypoxic injury increase incubation induced intracellular intron isolated kinase levels lifespan lipid liver lymphocytes macrophages mechanism membrane mice mitochondrial molecular mouse mRNA muscle Natl Acad Sci normal oxidative damage oxidatively modified oxygen peroxide phospholipids plasmid Podospora anserina populations prion Proc Natl Acad protein proteinase proteolysis proteolytic Prusiner SB receptor regulation replication scrapie senDNA senescence sequence span specific studies substrate superoxide tissue TK activity TK mRNA TK protein transfected vitro vivo yeast