Molecular biology of parasitic protozoa
Frontiers in Molecular Biology is a series of books designed to report on rapidly evolving, key areas of research in molecular biology. Individual chapters are written by leading researchers who are specialists in their fields. Each book is carefully organized to provide an integrated analysis of current progress in the area covered.
Parasitic protozoa cause major infectious diseases of humans and domestic animals. In recent years, new techniques in molecular biology have allowed tremendous advances in our understanding of these parasites. Molecular Biology of Parasitic Protozoa covers this fast-moving field at an advanced level for which there is no other up-to-date book. Topics covered include trypanosomatid and Toxoplasma genetics, structure and replication of kinetoplast DNA, regulation of gene expression in trypanosomes, trans-splicing, RNA editing, the three genomes of Plasmodium, mechanisms of drug resistance, biogenesis of glycosomes and hydrogenosomes, glycosylphosphatidylinositols and the surface architecture of parasitic protozoa.
Molecular Biology of Parasitic Protozoa is a unique compendium of current research findings in this important area. It contains over 900 references and provides a comprehensive review of the field as well as valuable insights and predictions of future progress by leading researchers.
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Requirements for gene expression
The three genomes of Plasmodium
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Acad activity African trypanosomes amino acid amplification analysis antigenic variation Biochem Biol bloodstream form Borst C-terminal Cell chloroquine chromosome cleavage cloned complex conserved Crithidia cytochrome oxidase developmental drug resistance EMBO enzyme ESAG eukaryotes fasciculata frans-splicing function gene expression genetic genome GIPLs glycosomal GPI anchors gRNA homologous hydrogenosomes infection intron involved kDNA kinetoplast kinetoplast DNA leader sequences Leishmania mammalian markers maxicircle mechanism membrane metacyclic minicircles mitochondrial molecular molecules mRNA mutations Natl nuclear Nucleic Acids Res nucleotides organelles organisms parasite Parasitol PARP pathway peroxisomal phenotype plasmid Plasmodium falciparum Ploeg polyadenylation polycistronic polymorphism pre-mRNA Proc procyclic form procyclin promoter protein protozoa pyrimethamine recombination region replication RNA editing RNA polymerase rRNA SL RNA snRNA specific spliced leader structure studies subtelomeric subunit surface glycoprotein targeting signal telomeric tion Toxoplasma gondii trans transcription unit transfection tRNA Trypanosoma brucei Trypanosoma cruzi trypanosomatids uridines vector vitro vivo VSG gene