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significance for metabolic disease
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3-globin gene abnormal allele amino acid amino acid sequence analysis apo C-III apolipoprotein atherosclerosis base pairs binding cDNA cent chain chromatin Class 3 allele clinical clone coding region codon common metabolic diseases complementary containing defect dependent diabetes diabetes mellitus diagnosis disorders DNA insertions DNA molecules DNA polymorphisms DNA sequence duplication eukaryotic exons fragments frequency function gene probe gene product genetic marker genotype globin glucose helix heterozygous homozygous hormone human genome human insulin hybridization hypercholesterolaemia hyperlipidaemia hypertriglyceridaemia identified individuals inheritance insulin gene introns involved isolated linkage lipid lipoprotein loci molecular mRNA normal nucleic acids nucleotide sequence nucleotides occur oligonucleotide patients pedigree peptide phage phenotype plasma plasmid point mutations polygenic polymorphic locus polymorphic variants population primary transcript promotor protein receptor recombinant DNA regulatory restriction enzyme ribosomes selection Southern blotting splicing strand structure studies synthesis tissues translation triglyceride tRNA Type I diabetes vector VLDL