Molecular Oncology of Breast Cancer
Jeffrey Stuart Ross, Gabriel N. Hortobagyi
Jones and Bartlett Publishers, 2005 - Medical - 500 pages
The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this ground-breaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up-to-date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.
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Screening and Early Detection Serum and Nipple Aspirates Routine and Molecular
Genomicand Molecular Classification of Breast Cancer
Clinical Sample Procurement and OnSlide Technologies
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activity adjuvant analysis angiogenesis antigen apoptosis assay associated binding Biol biomarkers biopsy BRCA1 BRCA2 breast cancer breast cancer cells breast cancer patients Breast Cancer Res breast carcinoma breast tumors Cancer Res Treat caspase cell cycle cell lines chemotherapy chromosome Clin Cancer Res Clin Oncol correlated cyclin D1 cytometry detection diagnostic disease DNA methylation drug E-cadherin EGFR estrogen receptor gene expression genetic genomic HER2 hormone human breast cancer IHC Yes inhibition inhibitor Int J Cancer levels lymph node markers metastasis metastatic metastatic breast cancer microarray molecular molecules monoclonal antibody mRNA mutations Natl Cancer Inst node-negative Oncogene outcome overexpression Paraffin Pathol pathway phase ploidy predictive predictor primary breast cancer prognostic factor prognostic significance proliferation proteasome protein response role samples serum signaling sion specific status studies survival tamoxifen target therapeutic therapy tion tissue transcription trastuzumab treatment tumor cells tumor suppressor tumor suppressor genes ubiquitination VEGF Yes Yes