Molecular Pathogenesis of Gastrointestinal Infections
Springer US, Nov 30, 1991 - Medical - 342 pages
The meeting that provided the material for this book was the 58th Symposium of the Federation of European Microbiological Societies (FEMS) entitled MOLECULAR PATHOGENESIS OF GASTROINTESTINAL INFECTIONS which was held in Helsingor, Denmark from 2nd to 4th September, 1990. The aim of this meeting was to bring together scientists from a range of discipline- microbiology, cell biology, molecular biology and immunology - to consider how microbes, including parasites, colonize and infect the gastrointestinal tract. The programme was designed to focus particular attention on the range of strategies whereby enterovirulent bacteria and parasites colonize the gastrointestinal mucin layer, how they adhere to and penetrate the epithelial layer by entering the cells or passing between them, and how various protein toxins may facilitate these processes. Speakers were especially encouraged to highlight the recent expansion in our knowledge of the molecular mechanisms by which enterotoxigenic and enteropathogenic Escherichia coli, shigellae, salmonellae and Yersinia enterocolitica cause intestinal disease. There were also discussions of recently-discovered gastrointestinal pathogens such as Clostridium difficile and Helicobacter pylori as well as accounts of how virulent determinants can be used to develop new diagnostic methods based on DNA gene probes and the polymerase chain reaction (PCR). These presentations provided the basis for the chapters in this book.
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THE MUCOSAL SURFACE
Characteristics of the Recognition of Host Cell
Structure and Properties of Rat Gastrointestinal Mucins
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activity adherence adhesins adhesion amino acid antibodies antigens assay bacteria binding blood group brush border cell surface CFA/I cfad cloned Clostridium Clostridium difficile coli strains colonization factor antigens components culture cytotoxic degradation detected diarrhoea difficile ELISA encoded enterocytes enteropathogenic enterotoxigenic Escherichia coli enterotoxin enzyme EPEC epithelial cells Escherichia coli ETEC expression fecal fimbriae gastric Gastrointestinal Infections gene genetic Giardia glycolipids glycoproteins glycosidases HEp-2 cells human hydrophobicity identified Immun incubation inhibition interaction intestinal intracellular invasion isolated mediated mice microbial Microbiol Molecular Pathogenesis mouse mucin mucosa mucus mutants Nucleotide sequence oligosaccharide operon Pathogenesis of Gastrointestinal pathogenic peptides phenotype plasmid probe produced purified rabbit receptor regulation regulatory role Salmonella typhimurium secretion serotype serum Shiga toxin Shiga-like toxin Shigella dysenteriae Shigella flexneri shown specific structure studies subunit tissue transcription trophozoites type 1 fimbriae urease vaccine Vibrio cholerae virB virulence vitro vivo Yersinia