Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects, Volume 2

Front Cover
Martin Clynes
Springer Science & Business Media, Jan 31, 1999 - Medical - 344 pages
Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
 

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Contents

Introduction
1
Brief History of Wires and Cables in Medicine and Technology
4
Chronology of Osteosyntheses
6
Wire Cables Stateoftheart Solution
12
Principle of Cable Osteosyntheses
19
Crimps
21
PESleeves
22
Instruments
23
Bilateral Cable Tension Band and its Biomechanical Analysis
66
Olecranon Fracture
77
Historical Procedures
78
Webers Olecranon Tension Band and its Biomechanical Analysis
80
Bilateral Cable Tension Band for Olecranon and Proximal Ulna Fractures
85
Ankle Joint and Pilon Fractures
93
Cable Tension Banding on the Medial Malleolus
94
Osseous Prominences
102

Cerclage Wire and Wire Cables A Comparison
26
Results
27
Tensile Strength of Twists and CableCrimp Connections
28
Tensile Strength of Bent Cerclage Wire
31
Evaluation of the Results
32
References in the Literature
33
Wire Cables in Everyday Hospital Life
34
Technical Instructions for Operations
35
Cerclage
36
SleeveCable Combinations
37
Stretching and Crimping
38
The Final Steps
39
Errors and Risks
40
The Mechanics of Bone Healing
43
Biomechanic of Tension Band Principle
44
Patella Fracture
51
Historical Procedures
52
Closed Adjustment
53
Open Bone Suture
54
Tension Banding
56
Webers Patella Tension Band and its Biomechanical Analysis
60
Trochanter Cable Tension Banding
105
Proximal Humerus and Tuberculum Majus
109
Cable Tension Banding on the Head of the Humerus and Tuberculum
110
Distal Humerus Fractures
115
Avulsion Fracture at the Base of the Fifth Metatarsal
117
Compression Cable Osteosynthesis
119
Corrective Osteotomy in the Knee Joint Region
122
Cable Arthrodeses
126
Cable Arthrodesis of the Upper Ankle Joint
127
Pirogoff Amputation with TibioCalcaneal Cable Arthrodesis
131
Cable Cerclages
135
SleeveCable Banding of Unstable Pelvic Ring Injuries
138
SleeveCable Osteosynthesis of Longitudinal Sternotomy
146
Soft Tissue Trauma Temporary Protection of Ligament Sutures Using a Cable
148
Quadriceps Tendon
150
Achilles Tendon
152
Quadriceps Tendon
153
Review and Outlook
170
References
171
Subject Index
183
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