Multiple Sclerosis

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Cambridge University Press, 1997 - Medical - 214 pages
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This concise, abundantly illustrated text provides a complete overview of multiple sclerosis. By including recent research findings in genetics, immunology and pathophysiology, the authors provide reliable and up-to-date guidance on the epidemiology, diagnosis, prognosis and treatment of MS. Of particular interest to neuroscientists and neurologists will be the reviews of experimental models of MS, pathology of the demyelinated plaque, HLA associations and the role of immune mechanisms. Contributors analyze the environmental and geographical factors in the etiology of MS, including the possible role of infectious agents. The clinical sections of the book include discussion of neurological, sexual, psychological and cognitive disturbances. A review of diagnostic criteria and rehabilitation measures are prominent features of this highly practical book.
 

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Contents

Historical perspective
3
Pathology and experimental models
7
Genetics and immunology
30
Epidemiology
49
Pathogenesis
54
Pathophysiology of impaired neural transmission
63
Clinical aspects
69
Symptomatology
71
Prognosis
121
Differential diagnosis
125
Assessment of performance ability and disability
131
Management and therapy
133
Symptomatic treatment and nutrition
135
Therapy
148
Assessment Scales
169
References
179

Diagnosis
87
Disease course
116

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Page 205 - Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12, 809-837.

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About the author (1997)

Jurg Kesselring is Head of the Department of Neurology and Neurorehabilitation, Rehabilitation Centre, Valens, Switzerland.

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