Mycobacteria is divided into two volumes. The first volume deals with the basic biology of mycobacteria. With its emphasis on the state of the art outlook, this volume includes taxonomy and molecular biology of mycobacteria, modern approaches for detection of mycobacteria, and immunology and immunization against tuberculosis. The second volume covers drug trestments for mycobacteria anad tuberculosis. It outlines trends of discovery and development of chemotherapy, starting from the mid-50's to present day uses of chemotherapy in treating AIDS, drug-resistant tuberculosis, and other non-tuberculosis mycobacterial diseases.
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BASIC CONCEPTS IN THE CHEMOTHERAPY
EXPERIMENTAL CHEMOTHERAPY OF MYCOBACTERIAL
CHEMOTHERAPY OF TUBERCULOSIS IN DEVELOPED
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6-month regimens acid Antimicrob Agents Chemother antituberculosis drugs bacilli bacterial bactericidal bactericidal activity bacteriological CFU counts chemotherapy of tuberculosis Chest chronic CLARI clarithromycin clofazimine combination continuation phase Controlled clinical trial controlled trial culture negative dapsone developing countries diagnosis disease dosage dose duration efficacy ethambutol ethionamide experimental extrapulmonary failure follow-up Gangadharam PRJ Grosset HIV infection Hong Kong initial intermittent intracellular isoniazid IUATLD leprae lesions Lung lymph node M.tb macrophages Medical Research Council mg daily mg/kg months mouse multidrug multidrug-resistant mutants Mycobacterium avium complex Mycobacterium leprae Mycobacterium tuberculosis ofloxacin population preventive therapy programs pulmonary tuberculosis pyrazinamide regimens of chemotherapy relapse rate resistance Rev Respir rifabutin rifampicin rifampin rifapentine short-course chemotherapy side effects smear smear-positive sparfloxacin spleen sputum sterilizing activity strains streptomycin susceptibility Table thiacetazone toxicity treated treatment of pulmonary treatment of tuberculosis Tubercle tubercle bacilli Tuberculosis Chemotherapy tuberculosis control vitro weeks