Myofibrillogenesis

Front Cover
Dipak K. Dube
Springer Science & Business Media, Oct 19, 2001 - Science - 270 pages
Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.
 

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Contents

Myofibrillogenesis in Cardiac Muscle
3
Dynamics of Contractile Proteins Constituting Myofibrils in Living Muscle Cells
17
Emergence of the First Myofibrils and Targeting Mechanisms Directing Sarcomere Assembly in Developing Cardiomyocytes
37
Tropomodulin An Important Player in Cardiac Myofibrillogenesis
55
Maintenance and Manipulation of Myofibrillar Organization
67
Maintaining the Fully Differentiated Cardiac Sarcomere
69
Manipulation of Myofibrillogenesis in Whole Hearts
83
Regulation of Expression of Myofibrillar Proteins
97
Signal Transduction in Myofibrillogenesis Cell Growth and Hypertrophy
139
Cytoskeletal Gene Expression in the Developing Cardiac Conduction System
149
Heart Development and Myofibrillar Organization
175
Onset of a Cardiac Phenotype in the Early Embryo
177
Cellular Molecular and Developmental Studies on Heart Development in Normal and Cardiac Mutant Axolotls Ambystoma mexicanum
203
Cardiomyopathy and Myofibrillar Organization
219
The Function of Normal and Familial Hypertrophic CardiomyopathyAssociated Tropomyosin
221
Cardiomyopathies and Myofibril Abnormalities
233

Molecular Regulation of Cardiac Myofibrillogenesis Roles of Serum Response Factor Nkx25 and GATA4
99
Regulation and Organization of Human Troponin Genes
125

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