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70 days acceleration activity adrenal Aerospace Medicine aldosterone angles of attack animals arterial aspect ratio Author's abstract Authors bedrest period bicycle ergometer Biologiya i Meditsina blood volume body calcium cardiac output cardiovascular centrifugation changes creatinine days of bedrest deconditioning decrease diuresis ergometer excretion experiment experimental fiber fineness ratio fluid function glucose heart rate hematocrit hypodynamia hypokinesia iiii immobilization increased investigate isometric isometric exercise isotonic Kosmicheskaya Biologiya LBNP llll Longuet-Higgens loss Mach numbers measured metabolism muscle NASA nitrogen normal nose observed orthostasis orthostatic tolerance percent performed physical exercises physiological plasma plasma volume Procedure and methods prolonged bedrest protein pullout pulse rats recovery recumbency response serum significant significantly simulated sodium stroke volume temperature test subjects tilt tilt-table tilt-table test tissue treadmill TTTT TTTT TTTT urinary urine venous volume transport water immersion wave wave-induced weeks weightlessness wing