NR Coregulators and Human Diseases

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World Scientific, 2008 - Medical - 602 pages
This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the OC classicOCO papers as well as perspectives on future directions for the field. Sample Chapter(s). Chapter 1: Nuclear Receptor Coregulators in Human Diseases (839 KB). Contents: Nuclear Receptor Coregulators in Human Diseases (R B Lanz et al.); p160 Coactivators: Critical Mediators of Transcriptional Activation by Nuclear Receptors (J H Kim & M R Stallcup); Regulation of Nuclear Hormone Receptor Functions by Ubiquitin-Proteasome Pathway (A Ismail et al.); Coregulators as Oncogenes and Tumor Suppressors (R Kumar & A E Gururaj); A Central Role of SRC-3/AIB1 in Tumorigenesis (J Yan et al.); Thyroid Hormone Receptors, Coregulators, and Disease (M L Privalsky); Androgen Receptor Coactivators in Prostate Cancer (N L Weigel & I U Agoulnik); PGC-1 and Metabolic Control in Skeletal and Cardiac Muscle (Z Arany & B M Spiegelman); Coregulators in Metabolic and Neurodegenerative Diseases (J N Feige et al.); Role of the RIP140 Corepressor in Metabolic Regulation (M G Parker et al.); Nuclear Receptor Corepressors and Metabolism (T Alenghat & M A Lazar); Coregulators in CNS Function and Disease (O C Meijer & E R de Kloet); Tissue Repair and Cancer Control Through PPARs and Their Coregulators (L Michalik & W Wahli); Coregulators and Inflammation (S Ghisletti & W Huang); Nuclear Receptor Coactivators in the Cardiovascular System (J-M Xu); Coregulators as Determinants of Selective Receptor Modulator (SRM) Activity (M C Pace & C L Smith); Coregulators in Toxicology (J Regg et al.); Nuclear Receptor Coactivators Co-ordinate Metabolic Responses to Hormonal and Environmental Stimuli (R M Evans et al.); Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (L L Grasfeder & D P McDonnell). Readership: Academic, medical students, residents, fellow and biomedical research students."
 

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Contents

Chapter 1 Nuclear Receptor Coregulators in Human Diseases Rainer B Lanz David M Lonard and Bert W OMalley
1
Critical Mediators of Transcriptional Activation by Nuclear Receptors Jeong Hoon Kim and Michael R Stallcup
135
Chapter 3 Regulation of Nuclear Hormone Receptor Functions by UbiquitinProteasome Pathway Ayesha Ismail Heath Catoe Sarath Dhananjayan and...
163
Chapter 4 Coregulators as Oncogenes and Tumor Suppressors Rakesh Kumar and Anupama E Gururaj
195
Chapter 5 A Central Role of SRC3AIB1 in Tumorigenesis Jun Yan Sophia Y Tsai and MingJer Tsai
219
Chapter 6 Thyroid Hormone Receptors Coregulators and Disease Martin L Privalsky
243
Chapter 7 Androgen Receptor Coactivators in Prostate Cancer Nancy L Weigel and Irina U Agoulnik
281
Chapter 8 PGC1 αand Metabolic Control in Skeletal and Cardiac Muscle Zolt Arany and Bruce M Spiegelman
301
Chapter 12 Coregulators in CNS Function and Disease OC Meijer and ER de Kloet
383
Chapter 13 Tissue Repair and Cancer Control through PPARs and Their Coregulators Liliane Michalik and Walter Wahli
409
Chapter 14 Coregulators and Inflammation Serena Ghisletti Wendy Huang and Christopher K Glass
441
Chapter 15 Nuclear Receptor Coactivators in the Cardiovascular System Jianming Xu
467
Chapter 16 Coregulators as Determinants of Selective Receptor Modulator SRM Activity Margaret C Pace and Carolyn L Smith
485
Chapter 17 Coregulators in Toxicology Jolle Regg Malin HedengranFaulds Manuela Hase Ingemar Pongratz and Janke Gustafsson
517
Chapter 18 Nuclear Receptor Coactivators Coordinate Metabolic Responses to Hormonal and Environmental Stimuli Ronald M Evans Michael Down...
539
Chapter 19 Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery Linda L Grasfeder and Donald P McDonnell
559

Chapter 9 Coregulators in Metabolic and Neurodegenerative Diseases Jrme N Feige Hiroyasu Yamamoto and Johan Auwerx
319
Chapter 10 Role of the RIP140 Corepressor in Metabolic Regulation Malcolm G Parker Mark Christian Evangelos Kiskinis Asha Seth Donna Nichol a...
343
Chapter 11 Nuclear Receptor Corepressors and Metabolism Theresa Alenghat and Mitchell A Lazar
357

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