NR Coregulators and Human Diseases
This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the OC classicOCO papers as well as perspectives on future directions for the field. Sample Chapter(s). Chapter 1: Nuclear Receptor Coregulators in Human Diseases (839 KB). Contents: Nuclear Receptor Coregulators in Human Diseases (R B Lanz et al.); p160 Coactivators: Critical Mediators of Transcriptional Activation by Nuclear Receptors (J H Kim & M R Stallcup); Regulation of Nuclear Hormone Receptor Functions by Ubiquitin-Proteasome Pathway (A Ismail et al.); Coregulators as Oncogenes and Tumor Suppressors (R Kumar & A E Gururaj); A Central Role of SRC-3/AIB1 in Tumorigenesis (J Yan et al.); Thyroid Hormone Receptors, Coregulators, and Disease (M L Privalsky); Androgen Receptor Coactivators in Prostate Cancer (N L Weigel & I U Agoulnik); PGC-1 and Metabolic Control in Skeletal and Cardiac Muscle (Z Arany & B M Spiegelman); Coregulators in Metabolic and Neurodegenerative Diseases (J N Feige et al.); Role of the RIP140 Corepressor in Metabolic Regulation (M G Parker et al.); Nuclear Receptor Corepressors and Metabolism (T Alenghat & M A Lazar); Coregulators in CNS Function and Disease (O C Meijer & E R de Kloet); Tissue Repair and Cancer Control Through PPARs and Their Coregulators (L Michalik & W Wahli); Coregulators and Inflammation (S Ghisletti & W Huang); Nuclear Receptor Coactivators in the Cardiovascular System (J-M Xu); Coregulators as Determinants of Selective Receptor Modulator (SRM) Activity (M C Pace & C L Smith); Coregulators in Toxicology (J Regg et al.); Nuclear Receptor Coactivators Co-ordinate Metabolic Responses to Hormonal and Environmental Stimuli (R M Evans et al.); Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (L L Grasfeder & D P McDonnell). Readership: Academic, medical students, residents, fellow and biomedical research students."
What people are saying - Write a review
We haven't found any reviews in the usual places.
Chapter 1 Nuclear Receptor Coregulators in Human Diseases Rainer B Lanz David M Lonard and Bert W OMalley
Critical Mediators of Transcriptional Activation by Nuclear Receptors Jeong Hoon Kim and Michael R Stallcup
Chapter 3 Regulation of Nuclear Hormone Receptor Functions by UbiquitinProteasome Pathway Ayesha Ismail Heath Catoe Sarath Dhananjayan and...
Chapter 4 Coregulators as Oncogenes and Tumor Suppressors Rakesh Kumar and Anupama E Gururaj
Chapter 5 A Central Role of SRC3AIB1 in Tumorigenesis Jun Yan Sophia Y Tsai and MingJer Tsai
Chapter 6 Thyroid Hormone Receptors Coregulators and Disease Martin L Privalsky
Chapter 7 Androgen Receptor Coactivators in Prostate Cancer Nancy L Weigel and Irina U Agoulnik
Chapter 8 PGC1 αand Metabolic Control in Skeletal and Cardiac Muscle Zolt Arany and Bruce M Spiegelman
Chapter 12 Coregulators in CNS Function and Disease OC Meijer and ER de Kloet
Chapter 13 Tissue Repair and Cancer Control through PPARs and Their Coregulators Liliane Michalik and Walter Wahli
Chapter 14 Coregulators and Inflammation Serena Ghisletti Wendy Huang and Christopher K Glass
Chapter 15 Nuclear Receptor Coactivators in the Cardiovascular System Jianming Xu
Chapter 16 Coregulators as Determinants of Selective Receptor Modulator SRM Activity Margaret C Pace and Carolyn L Smith
Chapter 17 Coregulators in Toxicology Joëlle Rüegg Malin HedengranFaulds Manuela Hase Ingemar Pongratz and JanÅke Gustafsson
Chapter 18 Nuclear Receptor Coactivators Coordinate Metabolic Responses to Hormonal and Environmental Stimuli Ronald M Evans Michael Down...
Chapter 19 Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery Linda L Grasfeder and Donald P McDonnell
Chapter 9 Coregulators in Metabolic and Neurodegenerative Diseases Jérôme N Feige Hiroyasu Yamamoto and Johan Auwerx
Chapter 10 Role of the RIP140 Corepressor in Metabolic Regulation Malcolm G Parker Mark Christian Evangelos Kiskinis Asha Seth Donna Nichol a...
Chapter 11 Nuclear Receptor Corepressors and Metabolism Theresa Alenghat and Mitchell A Lazar
Other editions - View all
Acad Sci USA acetylation agonist AIB1 androgen receptor associated binding Biochem Biol Chem brain breast cancer cancer cells Cancer Res carcinoma CARM1 cellular chromatin Clin coactivator cofactors complex coregulators corepressor degradation diabetes disease domain enhanced enzymes estrogen receptor function gene expression Genet glucocorticoid histone human induced inflammatory inhibition insulin interaction involved kinase knockout leukemia levels ligand liver LXXLL mechanism mediated Metab metabolic mice mitochondrial modulators Mol Cell Biol Mol Endocrinol molecular molecules mouse mRNA muscle mutations N-CoR Natl Acad Sci NCoR nuclear hormone receptors nuclear receptor Oncogene overexpression peroxisome proliferator-activated receptor phenotype phosphorylation polymorphism PPARs Proc Natl Acad proliferation promoter prostate cancer proteasome protein recep recruitment regulation repression response role scription SERMs signaling pathways Sirt1 SMRT specific studies syndrome tamoxifen target genes thyroid hormone receptor tion tissue transactivation transcription factors transcriptional activity translocation tumor ubiquitin v-erb