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Possible Mechanisms Underlying the Teratogenic Effects of Medicines
The Etiology of Central Nervous System Defects
4 In Vitro Embryo Cultures as a Method for the Study of Central
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abnormal acid addiction administration adult alcohol alterations amphetamine animals barbiturate behavioral Biochem Biol birth brain development Brain Res catecholamines central nervous system cerebellar cerebellum cerebral chronic clinical cortex culture days of age decreased deficits dendritic developmental diazepam differentiation dopamine doses drug early embryos ethanol experimental exposed factors fetal fetal alcohol syndrome fetus function gestation glucocorticoids granule cells growth Gynecol hippocampus hyperactivity hypothyroid impaired increased infants injection layer lead Legrand levels malformations marihuana maternal maturation McLaughlin metabolism methadone methylmercury mg/kg mice morphine mothers motor mouse myelin neonatal neurobehavioral neurons neurotransmitter newborn normal observed Obstet offspring ontogeny opiate opioid opioid-exposed perinatal period Pharmacol phenobarbital phenytoin postnatal pregnancy pregnant rats prenatal exposure protein pups Purkinje cells rat brain receptors reduced reported response retardation studies synaptic syndrome teratogenic Teratology thyroid hormone thyroxine tion treated treatment utero vitro withdrawal women Yanai Zagon