Neuroglycobiology

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Minoru Fukuda, Urs Rutishauser, Ronald L. Schnaar
Oxford University Press, 2005 - Medical - 229 pages
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Carbohydrates play a major role in the function and structure of the brain. In the past decade, tremendous progress has been made in understanding the structure, biosynthesis, and function of glycoconjugates found in the nervous system. The field of neuroglycobiology is now entering an exciting new phase with the use of molecular tools allowing us to manipulate the amount, as well as the temporal and spatially regulated expression, of those glycoconjugates. In recent years, we have gained important new knowledge on glycoproteins (polysialic acid, HNK-1 glycan), proteoglycans, and glycolipids.

'Neuroglycobiology' presents an integrative account of the latest developments in this field. This new volume in the Molecular and Cellular Neurobiology series starts by summarizing the historical background in identifying those glycoconjugates uniquely present in neural cells. It then goes on to summarize the current theories about their roles before considering future directions in research. This book presents an outstanding summary of the latest knowledge and perspectives in neural glycobiology.
 

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Contents

Polysialic acid in adult brain plasticity
39
Biosynthesis and function of HNK1 glycans
59
Acknowledgement
85
insights from genetic modifications
95
Synthesis and function of glycosphingolipids
115
CD9integrin complex with gangliosides
123
origin and function
133
Deficient glycoprotein glycosylation in humans and mice 757
157
Lysosomal glycosphingolipid storage diseases
199
Acknowledgements 275
215
Index
225
Copyright

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About the author (2005)

Recipient of the Karl Meyer Award from the Society for Glycobiology.

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