New Molecular Targets for Cancer Chemotherapy

Front Cover
CRC Press, Jun 27, 1994 - Medical - 236 pages
This book covers a wide range of novel biochemical targets that appear to be the best leads in terms of designing novel targets for anticancer drug design. New Molecular Targets for Cancer Chemotherapy is a unique, multi-disciplinary effort, with internationally respected authors from the fields of growth factor-receptor interaction, phosphoinositide and phospholipase signal transduction, and DNA-drug binding interactions. The science is placed in clinical context and illustrations explain how clinicians can incorporate a mechanistic, pharmacodynamic approach into early clinical trial design.
 

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Contents

Chapter
1
An Overview of the Regulation of PhospholipaseLinked Cell Signaling
31
Growth Factor Receptors as Targets
45
Protein Tyrosine Kinase Inhibitors
67
Chapter 5
81
Chapter 6
97
Chapter 7
121
Chapter 8
143
Chapter 9
159
Chapter 10
177
Chapter 11
195
Index
213
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