New Research on Autoantibodies
Claude T. Petrelli
Nova Publishers, 2008 - Medical - 213 pages
Autoantibodies are a group of antibodies (immune proteins) that mistakenly target and damage specific tissues or organs of the body. One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self" proteins. Usually the immune system is able to discriminate by recognising foreign substances (non-self) and ignoring the body's own cells (self), yet not overreact to non-threatening substances such as foods, dust and pollen, or beneficial microorganisms. It creates antibodies only when it perceives what it has been exposed to as a threat (non-self). When the immune system ceases to recognise one or more of the body's normal constituents as "self", it may produce autoantibodies that attack its own cells, tissues, and/or organs, causing inflammation and damage. The causes of this inappropriate action are varied and are not well understood, often resulting in a chronic auto-immune disorder. While there is not a direct link, it is thought that many cases of autoantibody production are due to a genetic predisposition combined with an environmental trigger (such as a viral illness or a prolonged exposure to certain toxic chemicals). Some families have been shown to have a high prevalence of auto-immune conditions; however, individual family members may have different auto-immune disorders or may never develop an auto-immune condition. Researchers believe that there may also be a hormonal component to the cause as many of the auto-immune conditions are more common in women of childbearing age. This book presents leading research from throughout the world.
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acquired hemophilia AECA anti anti-DNA antibodies anti-dsDNA anti-endothelial cell anti-PRL autoantibodies anti-PT anticoagulant antigen antiphospholipid antibodies antiphospholipid syndrome apoptosis apoptotic Arthritis Rheum assay associated autoimmune disease binding bioactivity cause cell antibodies circulation Clin Endocrinol Metab Clin Exp clinical coagulation complement correlation cross-react detection diagnosis disease activity disorders dsDNA ELISA endothelial cells epitopes factor VIII free PRL glomerular glomeruli hemophilia Heymann nephritis hyperprolactinemia immune complexes immunoglobulin Immunol induce infections inhibitors kidney lupus nephritis macroprolactin marker membrane mice molecular molecules monoclonal murine nephritogenic aags normal nucleosomes ocular Ophthalmol pathogenesis pathogenic aabs pathogenic IgG aabs patients with anti-PRL patients with macroprolactinemia patients with systemic peptide phospholipids phosphorylation pituitary plasma prevalence PRL-IgG complex production prolactin prolactinoma protein prothrombin rats receptors renal retinal retinopathy Rheumatol role sera SLE patients systemic lupus erythematosus target Thromb Haemost thrombosis titers treatment uveitis vasculitis