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Experimental Therapeutic and Biochemical Studies
Differential Sensitivity of Normal Marrow Myeloid
Activity of Mitoxantrone and Bisantrene in a Human
12 other sections not shown
acute leukemia administered agents American Cyanamid Company ametantrone amsacrine anthracenedione anthracycline anthraquinones antitumor activity assay biopsy bisantrene bone marrow Cancer Center Cancer Res cardiotoxicity CFU-C chemotherapy clinical investigation clinical trial colonies Coltman Company Medical Research compounds course of therapy cross-resistance Curative Cyanamid Company Medical cytotoxicity dactinomycin decrease DHAD dihydrochloride dose level dose-limiting doxorubicin evaluable hematologic Hoff human tumor cloning i.v. doses Increasing disease leukopenia lung lymphoma M. D. Anderson Hospital malignant median Medical Research Division melanoma mg/kg mg/m2 dose mice mild mitoxantrone mitoxantrone and bisantrene myelosuppression myocyte P388/mitoxantrone partial response patients pharmacokinetic Phase I clinical phase II studies phase II trials phlebitis plasma platelet count Raven Press remission Renal cell carcinoma resistance Rozencweig San Antonio sarcoma schedule sensitivity serum solid tumors Southwest Oncology Group studies of mitoxantrone synthesis Table TCFUs tissue treated tumor types University of Texas vitro weeks York