Novel Insights into Adipose Cell Functions

Front Cover
Karine Clément, Bruce M. Spiegelman
Springer Science & Business Media, Sep 14, 2010 - Medical - 160 pages
2 Reviews
Obesity is a disease of society and economic transition spreading at an epidemic pace throughout the world. According to the World Health Organization, obesity is defined as an increased or abnormal accumulation of body fat mass to the extent that individual’s health will be negatively affected. Overweight is thus being considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders.This volume provides the most up to date insights into the biology of a complex endocrine organ: the adipose tissue.
 

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Contents

Pathological Alteration of Human Adipose Tissue in Obesity
1
Dynamics of Human Adipose Tissue Regulatory Mechanisms and Consequences for Fat Cells and the Whole Body
15
Metabolism of Fatty Acids in Adipocytes
20
The Role of Hypoxia in Adipocyte Function and Dysfunction
45
A New Target for AntiObesity Therapy
61
A Multistep Process
67
Origins and Plasticity
76
Transcriptional Regulation of Brown and White Adipogenesis
89
Transcriptional Control of Gene Expression in Different Adipose Tissue Depots
93
Epigenetic Approaches to Adipose Biology
101
Metabolic and Angiogenic Consequences of the Presence or Absence of UCP1
111
Metabolic Responses to Weight Perturbation
121
Recent Insights from Extreme Human Phenotypes
134
Index
145
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About the author (2010)

Yves Christen is one of Europe's most prolific science writers. Trained at the Pasteur Institute in Paris, France, he holds his doctorate in immunogenetics, and master's degrees in psychology, biochemistry, and animal biology. The author or co-author of ten books, he has edited nine others. He is currently science editor of "Le Figaro Magazine.

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