Oesophogeal PH Monitoring for Gastro-Oesophogeal Reflux in Infants and Children
Long-term oesophageal pH monitoring has become widely accepted as the principle investigation for the diagnosis of gastro-oesophageal reflux pathology, especially in infants and children. Due to the number of publications applying this investigation technique, it has become necessary to standardize the various methodologies. It begins with an account of the embryology, anatomy and innervation of the upper gastrointestinal tract followed by symptoms and pathogenesis as well as an overview of the advantages and disadvantages of different investigation techniques.
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Development of the upper gastrointestinal tract
Symptomatology of gastrooesophageal reflux
Pathophysiology of GOR and its symptoms
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24 hour abnormal acid GOR adults alkaline reflux antimony electrodes apnoea area below pH asymptomatic infants awake cells cisapride Clin clinical correlation cutoff limit DeMeester detected diagnosis Digitrapper domperidone duration endoscopy episodes/hour evaluate feeding gastric acid gastric contents gastric emptying Gastroenterology gastroesophageal reflux gastroesophageal reflux disease Gaviscon glass electrodes GOR disease GOR pathology hiatus hernia incidence of GOR increased longest episode longest reflux episode LOSP lower esophageal sphincter manometry Memolog months motility mucosa normal ranges number of episodes number of reflux oesophageal clearance oesophageal pH monitoring parameters pathological patients Pediatr Pediatr Gastroenterol Nutr peptic oesophagitis peristalsis pH data pH monitoring data pH units physiological physiotherapy postprandial periods pressure preterm infants prone pulmonary aspiration recording devices reference electrode reflux disease reflux episodes reflux esophagitis Reflux index reflux oesophagitis regurgitation respiratory disease respiratory dysfunction scintigraphy sleep stomach swallowing symptoms technique theophylline therapy Vandenplas vomiting