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Genetic Events in Human Carcinogenesis
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Acad acid activity addition alterations analysis antibody antigen appears associated binding Biol breast cancer c-myc carcinogens carcinoma cause cDNA cell lines cellular changes chromosome clones complex containing cytoplasmic deletion demonstrated differentiation domain early effects encoding et al evidence expression formation function gene genetic genome growth factor human identified important increased indicate induced infection inhibition initiation interaction involved kinase Laboratory leukemia levels loss lung cancer lymphoma malignant mechanisms mice molecular mouse mutations Natl Nature normal observed occur oncogenes Origins patients phenotype platelet-derived growth factor possible present Proc progression proliferation promoter protein recent receptor region regulation replication response risk role Science sequence shown signal similar specific stimulation structure studies suggest T-cell tion tissue transcription transformation transgenic translocation tumor tyrosine viral virus vitro