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Genetics and orphan diseases HARRY HARRIS
The natural and unnatural IRMIN STERNLIEB
The chemistry of trientine HENRY B F DIXON
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abnormal gene activity administration allopurinol animal application approval biochemical CaEDTA chelating agent chelation therapy clinical trials Commission common diseases compound concentration copper metabolism costs cystinuria deficiency development programme DMPS dose drug development drugs for rare enzyme evaluate excretion of copper federal funding genetic human incentives indications intravenous investigators involved Journal kidney Laboratories lead poisoning levels liability liver major manufacturers Medicine metal molybdenum mutations oral orphan diseases Orphan Drug Act orphan drug development Orphan Products patients with Wilson's penicillamine pharmaceutical companies pharmaceutical industry plasma population potential problems Product Licence protein radiocopper rare diseases reactions regulatory responsibility Scheinberg side effects specific sponsor studies syndrome tax credits tetrathiomolybdate thalidomide therapeutic thiomolybdates Third World toxicity transamination treated treatment of Wilson's trien triethylene tetramine United urinary urine vaccines Wilson's disease zinc sulphate zinc therapy