Osteoarthritis: Diagnosis and Medical/surgical ManagementRoland W. Moskowitz Written by the foremost experts, this text is a comprehensive clinical reference on osteoarthritis. Chapters review current information on the epidemiology, etiopathogenesis, and pathology of osteoarthritis, the biochemistry and molecular and cell biology of articular cartilage, and experimental models of osteoarthritis. Major sections focus on clinical presentations, roentgenologic and laboratory diagnosis, and treatment, including pharmacologic treatment, intra-articular therapy, surgery, arthroscopy, and complementary and alternative medicine. The authors discuss the indications, outcomes, and complications of various orthopaedic procedures. Chapters present orthopaedic approaches to osteoarthritis of various joints—the shoulder, hand, wrist, elbow, hip, knee, foot, ankle, and cervical, thoracic, and lumbar spine. |
Contents
Epidemiology of Osteoarthritis | 3 |
Etiopathogenesis of Osteoarthritis | 27 |
Pathology of Osteoarthritis | 51 |
Cell Biology Biochemistry and Molecular Biology of Articular Cartilage in Osteoarthritis | 73 |
Experimental Models of Osteoarthritis | 107 |
Molecular Genetics of Osteoarthritis | 127 |
GENERAL ASPECTS OF DIAGNOSIS | 137 |
Osteoarthritis Clinical Presentations | 139 |
The Pharmacologic Treatment of Osteoarthritis | 267 |
IntraArticular Therapy | 287 |
Complementary and Alternative Medicine | 303 |
Study Design and Outcome Measures in Osteoarthritis Clinical Trials | 313 |
SURGICAL CONSIDERATIONS IN OSTEOARTHRITIS | 327 |
General Considerations Indications and Outcomes | 329 |
Upper Extremity Considerations Osteoarthritis of the Shoulder | 339 |
Upper Extremity Considerations Hand Wrist and Elbow | 349 |
Radiologic Diagnosis | 147 |
Magnetic Resonance Imaging | 167 |
Ultrasound and Alternative Imaging Outcomes | 193 |
Laboratory Findings in Osteoarthritis | 201 |
Noninvasive Biochemical Markers in Osteoarthritis | 215 |
Secondary Osteoarthritis | 233 |
GENERAL ASPECTS OF MANAGEMENT | 255 |
Baseline Program | 257 |