Patricia B. Hoyer
CRC Press, Apr 8, 2013 - Medical - 248 pages
In recent years, there has been an alarming increase in environmental by-products that may be harmful to ovarian function. Along with this dangerous situation, the modern trend toward delaying motherhood poses immediate concerns regarding the long-term impact of environmental risks on human fertility. The uncertainty of our reproductive future intensifies the need for a single reference that investigates the chemicals with the potential to jeopardize fertility.
The only known text that deals specifically with toxicity in the ovary, Ovarian Toxicology updates our current understanding of the effects of environmental chemicals on ovarian function. This new title in the Target Organ Toxicology Series presents an overview of ovarian physiology, examines the key ovarian target sites, assesses the effects of specific chemicals demonstrated in animal studies, and evaluates related human epidemiological data. Featuring the most complete review available of ovarian metabolism of xenobiotics, chapters also discuss ovarian cancer and modeling and testing for ovarian effects.
With its clear handling of data and issues that are crucial to fertility studies, this comprehensive exploration of ovarian toxicology identifies the realistic risks for damage that our environment has the potential to inflict. It will be welcomed by toxicologists and ovarian physiologists, those in the pharmaceutical industries and regulatory agencies, and postgraduate researchers striving to safeguard women's fertility and ensure our reproductive future.
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2 OVARIAN TOXICITY IN SMALL PREANTRAL FOLLICLES
3 OVARIAN TOXICITY CAUSED BY PESTICIDES
4 OVARIAN TOXICITY CAUSED BY ENDOCRINE DISRUPTORS
5 PHTHALATE TOXICITY IN THE OVARY
EFFECT ON REPRODUCTIVE FUNCTION AND MAMMARY GLAND TUMOR DEVELOPMENT
7 THE ROLE OF OVARIAN METABOLISM IN CHEMICALINDUCED OVARIAN INJURY
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2-bromopropane 4-vinylcyclohexene activity altered antral follicles apoptosis apoptotic Appl aromatase aromatic hydrocarbons aryl hydrocarbon associated atrazine atresia Biochem Biol carcinogenic caspase-3 caspases cell death chemicals chlorotriazines cisplatin compounds cytochrome decreased disruption dose effect of atrazine endocrine Environ environmental enzymes epithelial epoxide estradiol estrogen estrous cycles evaluated exposed exposure expression female rats follicular development gene germ cells gonadotropin granulosa cells Health herbicides hormone Hoyer human ovarian increased risk induced inhibition levels luteal mammary tumors Mattison mechanisms MEHP metabolites methoxychlor mice mRNA oocyte organochlorine ovarian cancer ovarian cancer cells ovarian failure ovarian follicles ovarian function ovarian metabolism ovarian toxicity ovary ovotoxic ovulation PAHs pathway percent pesticides Pharmacol pituitary pre-antral pre-ovulatory pregnancy primordial follicles progesterone prolactin protein rat ovary receptor Reprod reproductive risk of ovarian role secretion serum Sipes steroid steroidogenesis studies surge synthesis TCDD thecal cells tissue Toxicol Toxicology vaginal vitro vivo women xenobiotic XIAP