Ovarian Toxicology

Front Cover
Patricia B. Hoyer
CRC Press, Apr 8, 2013 - Medical - 248 pages
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In recent years, there has been an alarming increase in environmental by-products that may be harmful to ovarian function. Along with this dangerous situation, the modern trend toward delaying motherhood poses immediate concerns regarding the long-term impact of environmental risks on human fertility. The uncertainty of our reproductive future intensifies the need for a single reference that investigates the chemicals with the potential to jeopardize fertility.

The only known text that deals specifically with toxicity in the ovary, Ovarian Toxicology updates our current understanding of the effects of environmental chemicals on ovarian function. This new title in the Target Organ Toxicology Series presents an overview of ovarian physiology, examines the key ovarian target sites, assesses the effects of specific chemicals demonstrated in animal studies, and evaluates related human epidemiological data. Featuring the most complete review available of ovarian metabolism of xenobiotics, chapters also discuss ovarian cancer and modeling and testing for ovarian effects.

With its clear handling of data and issues that are crucial to fertility studies, this comprehensive exploration of ovarian toxicology identifies the realistic risks for damage that our environment has the potential to inflict. It will be welcomed by toxicologists and ovarian physiologists, those in the pharmaceutical industries and regulatory agencies, and postgraduate researchers striving to safeguard women's fertility and ensure our reproductive future.
 

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Contents

1 OVARIAN PHYSIOLOGY
1
2 OVARIAN TOXICITY IN SMALL PREANTRAL FOLLICLES
17
3 OVARIAN TOXICITY CAUSED BY PESTICIDES
41
4 OVARIAN TOXICITY CAUSED BY ENDOCRINE DISRUPTORS
62
5 PHTHALATE TOXICITY IN THE OVARY
87
EFFECT ON REPRODUCTIVE FUNCTION AND MAMMARY GLAND TUMOR DEVELOPMENT
96
7 THE ROLE OF OVARIAN METABOLISM IN CHEMICALINDUCED OVARIAN INJURY
116
8 PLACENTAL INDUCTION OF OVARIAN TOXICITY
135
POSSIBLE ROLES OF XLINKED INHIBITOR OF APOPTOSIS PROTEIN XIAP
150
THE ROLE OF REPRODUCTIVE FACTORS AND ENVIRONMENTAL CHEMICAL EXPOSURE
175
A METHODOLOGICAL OVERVIEW
206
INDEX
227
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