Oxford Handbook of Key Clinical Evidence
James Harrison, Kunal Kulkarni, Mohamed Baguneid, Bernard Prendergast
OUP Oxford, Sep 24, 2009 - Medical - 904 pages
The Oxford Handbook of Key Clinical Evidence provides an alternative to the burgeoning repositories of trial data for students, trainees and researchers looking for the key evidence affecting medical practice. Recognising the growing importance of evidence-based medicine (EBM) to both the study and practice of medicine and surgery, the editors have aimed to provide a quick-reference text that presents the key data, facts, and evidence informing medical and surgical practice. Introductory chapters give the 'uninitiated' reader a firm footing in the history of EBM and its current importance within medical science. Readers are introduced to the statistical methods and tools needed to critically analyse trial data, providing a key for the terms and statistical methods encountered in the book and within clinical research as a whole. Leading figures in the major specialties have selected and summarised the most important modern trials, creating a two-page format for each study which distils the key information. Highlighted boxes identify the study type and evidence-level attained, while analysis of the key message and impacts of the trial firmly place the evidence into a practical setting for the reader. Key study features and results are examined, while the difficulties or problems associated with the trials are outlined. This is essential reading for everyone with an interest in the fundemental evidence underpinning modern practice.
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1b Key message acute adverse events aimed to compare analysis aneurysm angioplasty antibiotic aspirin assess associated AUTHORS baseline benefit biopsy bleeding breast cancer CABG Calcipotriol cardiac cardiovascular carotid centres chemotherapy chronic ciclosporin clinical clopidogrel complications coronary artery corticosteroids death demonstrated diabetes Discussion This study dose doxycycline drug early efficacy EnglJ etoricoxib evaluate Exclusion failure Follow-up fractures heparin hepatitis hospital Impact improved Inclusion criteria increased infection infliximab inhibitors intentionally left blank intervention ischaemic ischaemic stroke Lancet laparoscopic long-term Median metformin Methods Patients methotrexate months morbidity mortality myocardial infarction ofthe oral outcomes overall survival placebo post-operative prednisolone prevention Primary endpoint Problems prostate psoriasis pulmonary radiotherapy randomised RCT EVIDENCE LEVEL recurrence reduced REFERENCE regimens renal resection Results Primary endpoint risk score Secondary endpoints seizure severe side effects significantly stent steroids stroke study aimed STUDY DESIGN surgery surgical symptoms tacrolimus tamoxifen therapy thrombolysis transplantation treated trial tumour ulcer