Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery

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Chas Bountra, Rajesh Munglani, William K. Schmidt
CRC Press, May 13, 2003 - Health & Fitness - 968 pages
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This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

 

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Contents

Chapter 1 MechanismBased Classifications of Painand Analgesic Drug Discovery
1
Chapter 2 Sites of Analgesic Action
9
Chapter 3 From Acute to Chronic Pain Peripheral and Central Mechanisms
29
Chapter 4 Central and Peripheral Components of Neuropathic Pain
45
Chapter 5 A New Perspective on Signal Transduction in Neuropathic Pain
71
Chapter 6 Pain and the Somatosensory Cortex
87
Chapter 7 Descending Pathways in Spinal Cord Stimulation and Pain Control
101
Chapter 8 Local Neuroimmune Interactions in Visceral Hyperalgesia
119
Chapter 38 Profile of NSAID + Opioid Combination Analgesics
491
Chapter 39 NSAIDs and COX2 Inhibitors
499
Chapter 40 COX2Specific Inhibitors
515
Chapter 41 NK Receptor Antagonists
523
Chapter 42 Vanilloids
531
Chapter 43 The Development of Bradykinin Antagonistsas Therapeutic Agents
539
Chapter 44 The Treatment of Neuropathic Pain
549
Chapter 45 NMethylDAspartate NMDA Receptors as a Target for Pain Therapy
559

Chapter 9 Pain Processing in the Periphery
135
Chapter 10 Neuroimaging of Pain
149
Chapter 11 Surrogate Models of Pain
161
Chapter 12 Acute Trauma and Postoperative Pain
171
Chapter 13 Effectiveness of Needling Techniques with Special Reference to Myofascial Pain Syndromes
179
Chapter 14 Advances in the Management of Spinal Pain and Radiofrequency Techniques
189
Chapter 15 Pulsed Radiofrequency Treatment of Chronic Neck Back Sympathetic and Peripheral NeuromaDerived Pain
213
Chapter 16 Spinal Cord Stimulation
223
Chapter 17 Spinal Endoscopy
239
Chapter 18 Cancer Pain Treatment
251
Chapter 19 Inflammatory Joint Disease and Pain
261
Chapter 20 Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen Pelvis and Bladder and Chronic Urogenital and Rectal Pain
269
Chapter 21 Nerve Injury Pain
293
Chapter 22 Sympathetically Maintained Pain
309
Chapter 23 Headache
321
Chapter 24 Psychological Factors in Measurement of Pain
331
Chapter 25 Challenges and Pitfalls of Clinical Trials
337
Chapter 26 Molecular Approaches to the Study of Pain
347
Chapter 27 Molecular Validation of Pain Targets
355
Chapter 28 Genetics of Pain
365
Chapter 29 Animal Models of Pain
377
Chapter 30 An Overview of Current and Investigational Drugs for the Treatmentof Acute and Chronic Pain
385
Chapter 31 Novel Mu Delta and Kappa Agonists
407
Chapter 32 DeltaReceptor Nonpeptide Agonists
421
Chapter 33 Peripheral Opioid Analgesia
427
Chapter 34 Profile of ADL 21294 an Opioid Antihyperalgesic Agent with Selectivity for Peripheral MuOpiate Receptors
435
Chapter 35 ControlledRelease Opioids
449
Chapter 36 NMDAReceptor Antagonists as Enhancers of Analgesic Activity
475
Chapter 37 CCK Antagonist Potentiation of Opioid Analgesia
485
Chapter Profile of Ketamine CPP Dextromethorphan and Memantine
575
Chapter 47 GV 196771 A a New Glycine Site Antagonist of the NMDA Receptor with Potent Antihyperalgesic Activity
585
Chapter 48 VoltageGated Sodium Channels and Pain
607
Chapter 49 Calcium Channel Antagonists and the Control of Pain
619
Chapter 50 Profile of Ziconotide SNX111
629
Chapter 51 Nitric Oxide Synthase Inhibitors and the Role of Nitric Oxide in Nociception
637
Chapter 52 Adenosine and Pain
649
Chapter 53 Adenosine Kinase Inhibition as a Therapeutic Approach to Analgesia
659
Chapter 54 P2X Purinergic Receptors for ATP in Nociception
671
Chapter 55 Somatostatin Receptors in Analgesia
677
Chapter 56 Cannabinoids
683
Chapter 57 Antinociceptive Effects of Centrally Administered Neurotrophic Factors
707
Chapter 58 Peripheral Neurotrophic Factors and Pain
721
Chapter 59 Profile of Tramadol and Tramadol Analogues
731
Chapter 60 Sumatriptan and Related 5HT1B 1D Receptor Agonists
743
Chapter 61 Cholinergic Approaches to Pain Therapy
749
Chapter 62 Analgesic Effects of Vedaclidine a Mixed AgonistAntagonist at Muscarinic Receptor Subtypes
763
Chapter 63 Gabapentin and Related Compounds
775
Chapter 64 The Role of Gabapentin in the Management of Neuropathic Pain
781
Chapter 65 New Local Anesthetic Analgesics
795
Chapter 66 Spinal Adrenergic Agonists for Intractable Cancer Pain
803
Chapter 67 Cellular Implantation for the Treatmentof Chronic Pain
815
Chapter 68 BoneSeeking Radiopharmaceuticalsto Palliate Painful Bone Metastases
835
Currently Marketed AnalgesicsUSA 19982001
857
21Year Survey of Analgesicsin Development for Treatment of Acuteor Chronic Pain
863
Further Readings
935
Index
949
Back Cover
976
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