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Milestones for the Chemical Synthesis of Proteins
Inhibition of AngiotensinConverting Enzyme Activity by Syn
Identification of AngiotensinConverting Enzyme Inhibitory
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AcOH amide amino acid amino acid analysis amino acid residues amino acid sequence amphiphilic analogs antagonistic assay binding Biochem Biol biological activity Biophys C-terminal cells Chem coacervation column concentration conformation coupling CuCl2 dimers disulfide DTRE2 Edman degradation effect elution endothelin enkephalin ester flow rate Fujii gel-filtration GLP-l gramicidin HBVp hCRF HOBt HPLC hydrolysis hydrophobic inhibition inhibitory interaction Japan Kimura liposomes M.Ueki membrane MeOH method ml/min molecular natriuretic peptide obtained Osaka oxidized Paim pardaxin pBNP peak Peptide Chemistry 1988 peptide synthesis phosphorylated porcine potency primary structure procedure protected peptide protecting groups Protein Protein Research Foundation PTHrP purified racemization RCM-Paim reaction reagent receptor resin Sephadex showed shown in Fig solid phase synthesis solvent spectra synthetic peptides Table Yajima Yanaihara yield