Peritoneal Carcinomatosis: Principles of Management

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Paul H. Sugarbaker
Springer Science & Business Media, Mar 31, 1996 - Medical - 434 pages
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Paul Sugarbaker and his colleagues have persevered in the study and treat ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and incompletely appreciated properties. These properties, coupled with the biologic behavior of many cancers, results in the seeding and growth of these cancers on the peritoneum. Many of these cancers remain localized to the peritoneum only, never metastasizing to other sites. One possible reason for this may be the obstruction of the afferent lymphatics on the undersurface of the diaphragm. The mucopolysaccharides produced by many of these neoplasma are probably viscous enough to obstruct these lymphatics, leading to the syndrome of pseudomyxoma peritonei. Many of the neoplasms taking residence on the peritoneum have extremely long cell-cycle times and are resistant to radiotherapy and many chemotherapeutic agents. How ever, much can be done for these patients - resection of primary cancers, omentectomies to reduce ascites formation, management of recurrent ascites, management of intestinal obstruction, nutritional care, and, hopefully, intraperitoneal chemotherapy. We have reviewed many of these problems in the past [1-7]. Dr. Sugarbaker and his colleagues have organized the current state of knowledge and technology for continuing use. The book provides a basis for thoughtful, prospective research planning. John S. Spratt, M. D. , F. A. C. S. Professor of Surgery The James Graham Brown Cancer Center University of Louisville Louisville, Kentucky References 1. Long RTL, Spratt JS, Dowling E.
 

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Contents

Metastatic inefficiency Intravascular and intraperitoneal implantation of cancer cells
1
Intraperitoneal immunotherapy of cancer A review of options for treatment
13
Pharmacokinetics of the peritonealplasma barrier after systemic mitomycin C administration
41
Peritonealplasma barrier
53
Patterns of spread of recurrent intraabdominal sarcoma
65
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology
79
In vitro pharmalogic rationale for intraperitoneal regional chemotherapy
101
Immunotherapy for peritoneal ovarian carcinoma metastasis using ex vivo expanded tumor infiltrating lymphocytes
115
Peritonectomy procedures
235
Progressive release of the left colon for a tension free colorectal or coloanal anastomosis
255
Radiology of peritoneal carcinomatosis
263
Methodologic considerations in treatment using intraperitoneal chemotherapy
289
Safety constiderations in the use of intraoperative intraperitoneal chemotherapy
311
Treatment of peritoneal carcinomatosis from colon or appendiceal cancer with induction intraperitoneal chemotherapy
317
Effects of postoperative intraperitoneal chemotherapy on peritoneal wound healing and adhesion formation
327
Current status of staging laparotomy in colorectal and ovarian cancer
337

Role of omentumassociated lymphoid tissue in the progression of peritoneal carcinomatosis
147
Cancer cell seeding during abdominal surgery Experimental studies
155
Krukenberg syndrome as a natural manifestation of tumor cell entrapment
163
Peritoneal carcinomatosis and radioimmunoguided surgery
193
Diffuse and gross peritoneal carcinomatosis treated by intraperitoneal hyperthermic chemoperfusion
211
Complications of heated intraperitioneal chemotherapy and strategies for prevention
221
Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis
359
Lasermode electrosurgery
375
Peritoneal access devices for intraperitoneal chemotherapy
387
A simplified approach to hyperthermic intraoperative intraperitoneal chemotherapy HIIC using a self retaining retractor
415
Index
423
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