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Approaches to the Detection of Interactive Effects
Geographical Correlations between Disease and Environmental
Matching and Confounding in the Design and Analysis of Epi
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1:1 matched animals approach Armitage ASN under H1 assessment association autocorrelation barycentric bias binary variables Biometrics Biometrika cancer carcinogenic case-control studies chemotherapy circulatory circulatory system clinical trials clinicians coefficients comparison complete disjunctive table confounding variable considered contingency table correlation covariance death decision decision problem decision theory decision-making defined discriminant procedure discussion distribution drug effects efficiency epidemiological error estimate evaluation example expected exposure given health services heart disease hypothesis important increase interaction interim analyses long term trial mathematical ment monitoring mortality multi-centre trial multiplicative multivariate nominal significance levels null hypothesis number of patients observed obtained odds ratio paper parameters Peto planning population possible practical probability problem prognostic factors proportion Pulmonary embolism random allocation regression relative risk repeated measurements response sample Section situation statistical methods statistician stopping rule strategy stratified analysis survival tion treatment difference tumours vaccination values variance