Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

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Oliver Kayser, Heribert Warzecha
John Wiley & Sons, May 21, 2012 - Medical - 647 pages
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This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations.
With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.
 

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Contents

Pharmaceutical Biotechnology and Industrial ApplicationsLearning
3
Prokaryotic Cells in Biotech Production
15
Mammalian Cells in Biotech Production
43
Biopharmaceuticals from Plants
59
Production of Biopharmaceuticals in Transgenic Animals
71
Shaping
113
Part Two Bringing the Drug into Action From Downstreaming
153
Downstream Processing
179
Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides
337
Scientific Technical and Economic Aspects of Vaccine Research
371
New Nanobiotechnological Strategies for the Development of Vectors
391
Development Production and Application
423
Presentation
440
In Silico and UltrahighThroughput Screenings uHTS in Drug
453
Metabolic Engineering of Medicinal Plants and Microorganisms for
491
Metabolomics as a Bioanalytical Tool for Characterization of Medicinal
527

Characterization of Recombinant Proteins
201
IO Formulation Strategies for Recombinant Protein and Related
235
Drug Approval in the European Union and United States
257
Legal
269
Biosimilar Drugs
285
Integration of Biotechnologies for the Development of Personalized
553
Xenotransplantation in Pharmaceutical Biotechnology
581
NutraceuticalsFunctional Foods for Improving Health and Preventing
599
Index
629
Copyright

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About the author (2012)

Oliver Kayser: Oliver Kayser received his PhD at the Free University Berlin in 1997 following his fellowship at the University of Gainesville, Florida, whereupon he entered the pharmaceutical biotechnology industry. He is currently a lecturer at the Department of Pharmaceutics, Biopharmacy and Biotechnology at the FU Berlin, working on new biotech drugs from natural sources and on the development of drug delivery carriers based on nanosuspension and solid lipid nanoparticle enterprise technologies.


Prof. Dr. Heribert Warzecha
Studied Pharmazie at the Johannes Gutenberg-Universit?t, Mainz. After completing his Ph.D. in 1998, he worked first as a postdoctoral fellow at Cornell, USA, and become associate Professor in w?rzburg in 2001. Since 2007 he is full Professor at the technical university of Darmstadt and became dean of the Institute of plant science in 2009.

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