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Mechanisms of dissolution of frusemidePVP solid dispersions
Doherty P York and R Davidson
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acrylic resins adsorbents adsorption adsorption isotherm adsorptive capacity amount of drug antacids aqueous CHR unit containing PCL crosslinked derived properties diffusion coefficient dissolution medium dissolution profiles dosage form drug delivery systems drug dissolved effect equation films finite dose flow rate formulation mixtures containing formulations containing HDPE Higuchi hydrocortisone hydrocortisone penetration hydrogels hydroxide increased initial hydrogel intranasal administration intravenous administration kaolin LDPE linear M. H. Rubinstein magnesium oxide magnesium trisilicate matrix membrane molecular weight nonionic surfactants observed pancreatic juice PEG dissolution PEO-PO Pharm PHARMACEUTICAL TECHNOLOGY phenobarbitone physical properties poloxamers polyethylene polyethylene glycol polymer polymeric polysorbate 20 porosity prolonged propranolol hydrochloride propylene glycol propylene glycol concentration propylene oxide Proxyphylline release rate resultant tablets RLPM RSPM salicylic acid samples secreted volume secretin skin slope solid dispersions solubility solution surface area surfactant Table tapped density values vehicles containing vitro dissolution volume of pancreatic w/w frusemide