PharmacoepidemiologyBrian L. Strom Not intended as a textbook of adverse drug reactions but rather as a way to elucidate the methods of investigating adverse drug reactions as well as other questions of drug effects. Section one gives an introduction to the field and presents basic scientific principles of clinical epidemiology. In this edition a chapter has been added on analogous basic principles of clinical pharmacology. A presentation of multiple different perspectives on clinical epidemiology can be found in the second section. Due to major new methodological developments in the field, sections three and four have had new chapters added and others removed. The first three sections will be of interest to the neophyte while sections two through four will appeal to those with some background who want a more in-depth view of the field. |
Contents
What is Pharmacoepidemiology? | 3 |
A Public Health Perspective from Academia | 69 |
A View from a Regulatory Agency | 87 |
Copyright | |
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addition adverse adverse drug adverse events analysis approach assessment association bias cancer case-control studies cause changes Chapter Clin clinical clinical trials collection compared conducted confounding considered cost databases detect determine diagnoses disease dose drug drug exposure effects epidemiologic estimate evaluation example experience exposed exposure factors findings given Health hospital identified important incidence increase indication individuals interest issues limited major marketing measures medical records methods monitoring myocardial infarction observed obtained occur oral outcome patients performed period pharmacoepidemiology pharmacy physicians population possible postmarketing potential practice prescribing prescription present problems question randomized reactions recall received records reports response risk safety sample selected sources specific standard statistical studies subjects surveillance Table therapy tion treatment trials utilization vaccine validity variable