The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently.
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Method and measurement in pharmacology
Absorption and distribution of drugs
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acetylcholine acid action activity agents agonists anaesthetics animals antagonists associated binding block blood body brain calcium cancer cardiac cause cells central changes channels Chapter chemical clinical compounds concentration decrease dependence depression discussed disease dopamine dose drugs effects enzyme evidence example excretion factors function gene given glucose growth half-life heart hormone human important increase inhibition inhibitors injection insulin interaction involved known less liver mainly mechanisms mediators membrane molecules myocardial infarction nerve nervous system neurons nicotine noradrenaline normal occurs orally pain particularly pathway patients peptide pharmacological phase plasma potential pressure prevent produce protein reactions receptors reduced regulation release response result role secretion selective shown similar smooth muscle specific stimulation structure studies substances sympathetic synthesis Table terminals therapeutic therapy tissue toxicity transmission transmitter transport treat treatment trials types unwanted effects various vascular
A Primer of Drug Action: A Concise Nontechnical Guide to the Actions, Uses ...
Robert M. Julien
Anteprima non disponibile - 2001
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International Review of Cytology
Anteprima limitata - 2001